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Due to the bitter taste, segments should be stored separately from whole tablets. Dosage Forms and Strengths. Ursodiol: 250 mg tablet Ursodiol: 500 mg scored tablet. Patients with complete biliary obstruction and known hypersensitivity or intolerance to Ursodiol or any of the components of the formulation. Patients with variceal bleeding, hepatic encephalopathy, ascites or in need of an urgent liver transplant, should receive appropriate specific treatment. Abnormal Liver Function Tests. Liver function tests (?-GT, alkaline phosphatase, AST, ALT) and bilirubin levels should be monitored every month for three months after start of therapy, and every six months thereafter. This monitoring will allow the early detection of a possible deterioration of the hepatic function. Treatment discontinuation should be considered if the above parameters increase to a level considered clinically significant in patients with stable historical liver function test levels. Caution has to be exercised to maintain the bile flow of the patients taking Ursodiol. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. The following table summarizes the adverse reactions observed in two placebo-controlled clinical trials. ADVERSE REACTIONS VISIT AT 12 MONTHS VISIT AT 24 MONTHS UDCA n (%) Placebo n (%) UDCA n (%) Placebo n (%) Diarrhea — — 1 (1. UDCA = Ursodeoxycholic acid = Ursodiol. In a randomized, cross-over study in sixty PBC patients, seven patients (11, olympus labs uk superdrol. One patient on the twice a day regimen (total dose 1000 mg) withdrew due to nausea. All of these nine adverse reactions except esophagitis were observed with the twice a day regimen at a total daily dose of 1000 mg or greater. However, an adverse reaction may occur at any dose. The following adverse reactions, presented by system organ class in alphabetical order, have been identified during post approval use of Ursodiol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Gastrointestinal disorders : abdominal discomfort, abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting. General disorders and administration site conditions : malaise, peripheral edema, pyrexia. Hepatobiliary disorders: jaundice (or aggravation of pre-existing jaundice). Immune System Disorders : Drug hypersensitivity to include facial edema, urticaria, angioedema and laryngeal edema. Abnormal Laboratory Tests: ALT increased, AST increased, blood alkaline phosphatase increased, blood bilirubin increased, ?-GT increased, hepatic enzyme increased, liver function test abnormal, transaminases increased.
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