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In the early 2000s, the aromatase inhibitors: Arimidex (chemical name: anastrozole) Aromasin (chemical name: exemestane) Femara (chemical name: letrozole) were shown to be more effective at reducing recurrence risk in postmenopausal women and are now used more often than tamoxifen to treat women who’ve gone through menopause. Aromatase inhibitors aren’t commonly used to reduce recurrence risk in premenopausal women. Most women take hormonal therapy for 5 to 10 years after breast cancer surgery. For people diagnosed with DCIS, ADH, or LCIS, the treatment is most commonly 5 years of tamoxifen, at a dose of 20 mg per day, after surgery to remove the abnormal cells. Still, like most cancer medicines, both tamoxifen and aromatase inhibitors can cause side effects. Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones. Endometrial cancer is a less common but more severe side effect of tamoxifen. Other research has shown that about 25% of women who are prescribed hormonal therapy to reduce the risk of recurrence after breast cancer surgery either don’t start taking the medicine or stop taking it early, in many cases because of side effects. Could a lower dose of tamoxifen effectively reduce invasive disease risk? Because so many women stop taking tamoxifen early, researchers wondered if a lower dose of tamoxifen could still reduce the risk of invasive breast cancer and cause fewer or less severe side effects. In this Italian study, called the TAM-01 trial, the researchers randomly assigned 500 women diagnosed with DCIS, ADH, or LCIS to one of two treatments after surgery (and radiation, if needed): 253 women took 5 mg of tamoxifen once per day for 3 years. 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