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In osteoclast-dependent or osteocalcin-dependent bone production, these processes are mediated by osteocalcin, with varying amounts of osteocalcin being detected in the bone marrow and bone marrow precursors. However osteocalcin is present in non-neuronal bone and is involved in the transport and degradation of various non-neural growth factors including the growth factors and the interphase intermediate, interphase interconverting enzymes. As noted above, there is an interaction between osteocalcin and growth factors that affect osteoblasts. These are some of the factors that may be involved in bone resorption in bone marrow: [6,7,8,9,10]
The release of interphase mediators, i.e., osteocalcin, inhibits the proliferation of osteoblast precursor cells by inducing apoptosis. These mediators are transported, bound to osteocalcin, and are then used to form an intermediate that inhibits the formation of new bone in osteoblasts (called a ‘collagen/osteoclast interface'[12]). The formation of this interface leads to an increase in the production of collagen-4 which in turn leads to the appearance of new bone cells. The loss of collagen
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