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El analisis mostro que mas alla del periodo de estudio, el exemestano redujo el riesgo de recurrencia de cancer de mama 24% en comparacion con el tamoxifeno (indice de riesgo 0. El efecto benefico de exemestano sobre el tamoxifeno respecto a la supervivencia libre de enfermedad, fue aparentemente independiente del estado ganglionar o de una quimioterapia previa. De igual forma, el exemestano produjo una reduccion significativa del riesgo de cancer de mama contralateral (indice de riesgo 0. Resultados de un subestudio endometrial indicaron que despues de 2 anos de tratamiento hubo una mediana de reduccion en el grosor endometrial de 33% en los pacientes tratados con exemestano en comparacion con una no notable variacion en los pacientes tratados con tamoxifeno. El engrosamiento endometrial, reportado al inicio del tratamiento de estudio, revirtio a la normalidad en 54% de los pacientes tratados con exemestano. 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Asimismo, los pacientes tratados con exemestano presentaron un mayor indice de respuesta al tumor objetivo, en comparacion con el tamoxifeno (44 vs. En un estudio clinico, controlado, aleatorizado y revisado por expertos, se demostro que la dosis diaria de 25 mg de exemestano produce un aumento estadisticamente significativo en la supervivencia, del Tiempo hasta la Progresion (TTP) y del Tiempo hasta el Fracaso del Tratamiento (TFT), en comparacion con el tratamiento hormonal estandar con acetato de megestrol en pacientes posmenopausicas con cancer de mama avanzado, que ha progresado despues o durante el tratamiento con tamoxifeno, ya sea como terapia coadyuvante o como tratamiento de primera linea para la enfermedad avanzada. Absorcion: Despues de la administracion oral, el exemestano se absorbe rapidamente. La fraccion de la dosis que se absorbe en el tracto gastrointestinal es alta. 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