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This study is a great example of the anabolic effect ostarine has on the body: Ostarine treatment resulted in a dose dependent increase in total LBM, with an increase of 1.6%, 2.6% and 2.9%, respectively. This increase in total LBM is greater than the increases we observed in the healthy subjects, suggesting that ostarine improves athletic performance.
Although the mechanisms underlying the changes in the LBM to fat ratio are not well understood, a possible mechanism is enhanced metabolic rate, since the decrease in resting metabolic rate may result in greater metabolism in ostarine-treated animals. The study was conducted in laboratory animals by using a method known as indirect calorimetry to evaluate fat oxidation, which allows an indirect assessment of anabolic activity. Therefore, an increase in the energy expenditure during exercise may be an indicator of an increase in anabolism. However, the lack of correlation between the resting metabolic rate and the ostarine concentration in the blood may mean that there are other, more likely explanations. This study may therefore be used as a proof-of-concept to investigate the potential role of ostarine in the enhancement of anabolic resistance.
The increase of the LBM compared to healthy control animals can be used to infer that ostarine improves athletic performance. This observation suggests that ostarine might be used as a novel weight loss drug in the long run, but further research is needed to confirm this hypothesis. In principle, it would be very interesting for the future to test ostarine by conducting several studies, since Ostarine can have both an anabolic and anabolic actions on the body.
Acknowledgments
The authors thank Prof J. A. van der Velden in the field of oculomandibular dysfunction at the University of Groningen.
References
1. Beyer JA Vollenweider F , et al. Muscle and bone remodeling is impaired in a mouse model of chronic bone dislocations and osteoporosis . Science . 1999 ; 284 : 2477 – 2481 . 2. D’Odorico L Fonzo M Mazzoleni G , et al. Mechanism of action of L-arginine for the prevention of osteoporosis in women . Clin Sci (Lond) . 2003 ; 85 : 633 – 642 . 3. Harnett WJ DeRubeis N Rauch SJ , et al. Osteoporosis: treatment with L-arginine supplementation reverses bone loss in the femur of obese postmenopausal women . J Bone Miner Res . 2007 ; 25 : 1785 –
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