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The model was built with o (24) and refined by cns (25) by using a maximum likelihood target, bulk solvent correction, simulated annealing, noncrystallographic symmetry constraint and restraint, and restrained individual B factors. See Table 1 for details on data collection and refinement. There are two ERαLBDs in the crystallographic asymmetric unit related by a nearly exact noncrystallographic dyad, the answer the ultimate fat burner. This arrangement, which resembles that of unliganded RXR, likely represents the physiologically relevant homodimeric form of ERα in estrogen-dependent transcriptional activation (26), and corresponds to the stoichiometry and rotational symmetry of the ER’s DNA target (27). The fold of the individual ERαLBD is roughly similar to that seen in the structures of other liganded LBDs in the steroid/nuclear superfamily (1.
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