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This study is a great example of the anabolic effect ostarine has on the body: Ostarine treatment resulted in a dose dependent increase in total LBM, with an increase of 1.56 kg in the first week of treatment compared to a 0.67 kg per month increase in the placebo group.
The researchers say their findings add to the growing evidence of ostarine’s anabolic potential in vivo.
How does ostarine work?
Ostarine is a natural hormone secreted throughout the body. It works on two cellular targets: anabolic hormones and metabolic pathways. Specifically, ostarine is believed to play a role in protein synthesis. In a nutshell, ostarine helps to activate proteins necessary for muscle growth.
Another example of how ostarine’s role in muscle growth is thought to work is known as anabolism. This refers to the process where a hormone can alter cellular metabolism. Research on ostarine in muscle growth has highlighted that the compound can help modulate growth and development of myofibrillar proteins, which are vital to muscle hypertrophy.
The effects of creatine
The researchers of this study, led by Dr. John R. Sothern from Wake Forest School of Medicine, examined the effects of creatine supplementation in young and old men.
The researchers administered a 6-month treatment program to a total of 20 male subjects by intravenous infusion.
After supplementation, plasma creatinine levels in the young group were significantly higher than in the placebo group (6.9 milliliters versus 3.7 milliliters per kg, respectively). Muscle strength increased (p = 0.038, 0% vs. 0%) and the strength of the quadriceps femoris increased (p = 0.004, 40% vs. 21%). Also, the increase in LBM in the young group was statistically significant (p = 0.000, 20% vs. 12%).
In addition, the investigators found ostarine significantly boosted creatine levels in the young group, suggesting that creatine may be helping to enhance muscle growth.
These data indicate that in young men, the presence of ostarine increased the body’s endogenous production of creatine. In addition, they found increases in both total and free creatine.
In the subjects who had a history of creatine supplementation during their childhood, the levels of both the levels of free creatine and the creatine in serum were markedly increased after ostarine treatment. This suggests that in young men, supplementing with creatinine may help prevent age-related increases in the breakdown of creatine.
This increase in the levels of creatine that occurred after
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