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Grupa farmacoterapeutica: terapia vezicii biliare, preparate continand acizi biliari. Modificari calitative si cantitative ale functiei biliare, inclusiv formele de secretie biliara suprasaturate cu colesterol, pentru prevenirea formarii litiazei biliare sau pentru a crea conditii favorabile dizolvarii calculilor biliari transparenti radiografic, cu diametrul sub 15 mm; in special calculii biliari din vezica biliara si calculii reziduali sau recurenti din coledoc dupa interventia chirurgicala pe caile biliare; functia. Hepatite cronice insotite de colestaza (in particular ciroza biliara. Pentru dizolvarea calculilor biliari cu continut de colesterol, doza este de 300-600 mg pe zi (dupa sau in timpul meselor) coreaspunzator la 2-4 comprimate de Ursochol a 150 mg sau 1-2 comprimate Ursochol a. Pentru a mentine conditiile favorabile pentru dizolvarea calculilor biliari existenti, tratamentul trebuie sa dureze cel putin 4-6 luni pana la 12 luni sau mai mult, in functie de dimensiunea calculilor si evolutia sub tratament. Pentru tratamentul de mentinere sunt suficiente doze de 150 mg de 2 ori pe zi sau de 300 mg o data pe zi. In sindroamele dispeptice biliare, doza este de 1 comprimat a 150 mg de 2 ori pe zi. In hepatopatii cronice cu colestaza doza poate fi crescuta pana la 300 mg de 2-3 ori pe zi. Durata tratamentului trebuie hotarata de medic in functie atat de tipul si severitatea afectiunii cat si de raspunsul terapeutic. Dozele pot fi modificate de medic. Se recomanda analiza preliminara a transaminazelor si a fosfatazei alcaline inainte de inceperea tratamentului de lunga durata de dizolvare a calculilor biliari. De la inceput trebuie stiut ca tratamentul cu AUDC este indicat numai pentru dizolvarea calculilor biliari de natura colesterolica; un indiciu sigur. Calculii biliari care pot fi mai usor dizolvati. Eficacitatea tratamentului pentru dizolvarea calculilor biliari poate fi stabilita prin analize colecistografice/ecografice la perioade de 6 ‘ 10 luni. Nu s-au observat interactiuni severe. Medicamentele hipolipemiante, de tipul colestiraminei sau colestipolului, si antiacidele ce contin hidroxid de aluminiu – trisilicat de magneziu pot diminua absorbtia UDCA si, astfel, pot diminua efectul medicamentului. Nu este recomandata administrarea la pacientii. Aceste medicamente cresc secretia de colesterol in bila si scad eficacitatea tratamentului. Contraceptivele orale, estrogenii si dietele. Ursochol poate creste absorbtia ciclosporinei din intestin. De aceea, pacientilor tratati cu ciclosporina trebuie sa li se monitorizeze concentratiile plasmatice de ciclosporina si daca este necesar se vor ajusta dozele de ciclosporina. In cazuri izolate, Ursochol poate reduce absorbtia ciprofloxacinei, melanotan i 10 mg peptides $23.00. Trebuie atentionati sa nu utilizeze acest medicament: pacientii care au colici biliare frecvente, cu infectii grave, modificari ale pancreasului sau afectiuni intestinale care pot afecta circulatia enterohepatica a acizilor biliari (rezectia sau ileostomia, ileita regionala). Deoarece medicamentul contine lactoza, administrarea nu este recomandata la pacientii cu intoleranta. Tratamentul nu se administreaza la copii.
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