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It is also relevant to note that the rats were intact, meaning they had not been circumcised (much to the rats’ relief, I am sure), increasing the relevance to human application. To provide an accurate assessment of the study findings, it is best to quote the authors’ conclusion: ‘In conclusion, 2 mg/kg/day TREN treatment of eugonadal rats improved body composition, lipid profile and insulin sensitivity without: (1) adverse cardiovascular effects or increasing myocardial susceptibility to I/R injury; and (2) compromised hepatic structure or function. Further investigation into the comparative benefits conferred by trenbolone therapy relative to the current gold standard, testosterone, are well justified by these findings, usa steroids.com. Changes in Body Composition The most relevant effects for bodybuilders are the body composition changes seen with trenbolone treatment. The control rats that did NOT receive trenbolone gained eight percent body mass over the course of the study, with all of that gain (and then some) accounted for by an increase in fat mass. Body composition was measured by DEXA, so the results are reliable. The trenbolone-treated rats did not gain any significant mass during treatment. HOWEVER, there was a significant increase in lean mass, with a concordant reduction in fat mass. The trenbolone-treated rats saw a gain of 11 percent in lean mass, and dropped 37 percent of fat mass. Compare that to the unchanged lean mass of the control rats and 34 percent increase in fat mass. The results would be outrageous in a human study. This change in body composition was not overtly stressful to the organs or metabolism of the rats. In fact, the opposite occurred’ as it was discovered that the body became more sensitive to the signaling function of insulin. 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