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No serious adverse reactions were reported. CONCLUSIONS: Subcutaneous administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-I levels in healthy adults and was safe and relatively well tolerated, particularly at doses of 30 or 60 microg/kg. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent. J Clin Endocrinol Metab. Epub 2005 Dec 13. CONTEXT: Pulsatile GH secretion is considered important for many of the hormone’s physiological effects. Short-term GHRH infusions enhance GH pulsatility and increase IGF-I, but the short GHRH half-life limits its therapeutic use. A synthetic GHRH analog (CJC-1295) that binds permanently to endogenous albumin after injection (half-life = 8 d) stimulates GH and IGF-I secretion in several animal species and in normal human subjects and enhances growth in rats. OBJECTIVE: Our objective was to assess GH pulsatility after a single injection of CJC-1295 and determine which GH secretion parameters correlated to the increase in IGF-I production. METHODS: GH pulsatility was assessed by 20-min blood sampling during an overnight 12-h period in healthy 20- to 40-yr-old men before and 1 wk after injection of either 60 or 90 microg/kg CJC-1295. RESULTS: GH secretion was increased after CJC-1295 administration with preserved pulsatility. The frequency and magnitude of GH secretory pulses were unaltered. However, basal (trough) GH levels were markedly increased (7. CONCLUSIONS: CJC-1295 increased trough and mean GH secretion and IGF-I production with preserved GH pulsatility. The marked enhancement of trough GH levels by continuous GHRH stimulation implicates the importance of this effect on increasing IGF-I. Long-acting GHRH preparations may have clinical utility in patients with intact pituitary GH secretory capability, gp m1t 10 mg oral steroids m1t. J Clin Endocrinol Metab. Epub 2006 Oct 3. CJC-1295 Decay Rate Chart A single dose of CJC-1295 ‘decays’ by about 10% a day. So that single dose will follow the ‘effectiveness’ percentages indicated below over the week: _______ Dose ( 2mg ) Day 0 ‘ 100 % (2mg) Day 1 ‘ 90 % ( 1. GHRP-6 (10mg x 10) Product Description. Growth hormone-releasing peptide-6 is a synthetic hexapeptide and a met-enkephalin derivative that contains a chain of 6 unnatural D amino acids namely L-Histidine, D-Tryptophan, L-Alanine, L-Tryptophan, D-Phenylalanine and L-Lysine. It is the first hexapeptide studied in animal test subjects and was identified more than a decade ago. It belongs in the family of the Human Growth Hormone secretagogue, a substance that causes secretion of a separate substance.
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