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If conception results, rapid progression to the severe form of the syndrome may occur. To minimize the hazard associated with occasional abnormal ovarian enlargement associated with clomiphene citrate, the lowest dose consistent with expected clinical results should be used. The patient should be instructed to inform the physician of any abdominal or pelvic pain, weight gain, discomfort or distension after taking clomiphene citrate. Maximal enlargement of the ovary, whether physiologic or abnormal, may not occur until several days after discontinuation of the recommended dose of clomiphene citrate. Some patients with PCOS who are unusually sensitive to gonadotropin may have an exaggerated response to usual doses of clomiphene citrate. Therefore, patients with PCOS should be started on the lowest recommended dose and shortest treatment duration for the first course of therapy. If enlargement of the ovary occurs, additional clomiphene citrate should not be given until the ovaries have returned to pre-treatment size, and the dosage or duration of the next course should be reduced. Ovarian enlargement and cyst formation associated with clomiphene citrate usually regress spontaneously within a few days or weeks after discontinuing treatment. The potential benefit of subsequent clomiphene citrate therapy in these cases should exceed the risk. The dosage and/or duration of the next course of treatment should be reduced. Unless surgical indication for laparotomy exists, such cystic enlargement should always be managed conservatively. A causal relationship between ovarian hyperstimulation and ovarian cancer has not been determined. However, because a correlation between ovarian cancer and nulliparity, infertility and age has been suggested, if ovarian cysts do not regress spontaneously, a thorough evaluation should be performed to rule out the presence of ovarian neoplasia. There have been rare reports of ovarian cancer with fertility drugs; infertility itself is a primary risk factor. Epidemiological data suggest that prolonged use of clomiphene citrate may increase the risk of a borderline or invasive ovarian tumour. Foetal/Neonatal Anomalies and Mortality. The following foetal abnormalities have been reported subsequent to pregnancies following ovulation induction therapy with clomiphene citrate during clinical trials. Each of the following foetal abnormalities was reported at a rate of 1%; n = 8,029*) Fertomid-25. Clomifene (Fertomid) is primarily used by women who are having difficulty produce ova to become pregnant. Wat u misschien ook aanspreekt. Generic Name: Clomiphene Citrate. Strips of 10 Fertomid 25mg Tablets Manufactured by Cipla, buy testopro 10 amps (100 mg) injectable steroids testosterone propionate. Fertomid is used to induce ova production in women who are having difficulty becoming pregnant. It is also used in smaller doses by men to increase sperm production. You must see your doctor before using Fertomid for this purpose.
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