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In the extended adjuvant setting, the reported drug-related adverse reactions that were significantly different from placebo were hot flashes, arthralgia/arthritis, and myalgia. Table 3: Adverse Reactions Occurring in at least 5% of Patient in either Treatment Arm. Number (%) of Patients with Grade 1-4 Adverse Reaction Number (%) of Patients with Grade 3-4 Adverse Reaction Letrozole tablets N=2563 Placebo N=2573 Letrozole tablets N=2563 Placebo N=2573 Any Adverse Reaction 2232 (87. The incidence of self-reported osteoporosis was higher in patients who received Letrozole tablets 6. Bisphosphonates were administered to 21. The incidence of cardiovascular ischemic events from the core randomized study was comparable between patients who received Letrozole tablets 6. A patient-reported measure that captures treatment impact on important symptoms associated with estrogen deficiency demonstrated a difference in favor of placebo for vasomotor and sexual symptom domains. Bone Substudy: [see Warnings and Precautions (5. Lipid Substudy: In the extended adjuvant setting, based on a median duration of follow-up of 62 months, there was no significant difference between Letrozole tablets and placebo in total cholesterol or in any lipid fraction at any time over 5 years. Use of lipid lowering drugs or dietary management of elevated lipids was allowed. Updated Analysis, Extended Adjuvant Treatment of Early Breast Cancer, Median Treatment Duration of 60 Months The extended adjuvant treatment trial (MA-17) was unblinded early [ see Adverse Reactions ( 6 ) ]. At the updated (final analysis), overall the side effects seen were consistent to those seen at a median treatment duration of 24 months, testoviron depot 125 mg injectable steroids $78.00 testosterone enanthate. During treatment or within 30 days of stopping treatment (median duration of treatment 60 months) a higher rate of fractures was observed for Letrozole tablets (10. Based on 62 months median duration of follow-up in the randomized Letrozole arm in the Safety population the incidence of new fractures at any time after randomization was 13. The incidence of new osteoporosis was 14. During treatment or within 30 days of stopping treatment (median duration of treatment 60 months) the incidence of cardiovascular events was 9. Based on 62 months median duration of follow-up in the randomized Letrozole arm in the Safety population the incidence of cardiovascular disease at any time after randomization was 14. Lipid substudy: In the extended adjuvant setting (MA-17), based on a median duration of follow-up of 62 months, there was no significant difference between Letrozole tablets and placebo in total cholesterol or in any lipid fraction over 5 years. Use of lipid lowering drugs or dietary management of elevated lipids was allowed. First-Line Treatment of Advanced Breast Cancer. 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