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This is because orals are c-17 alpha alkylated, meaning they are processed by the liver before entering the blood stream. Consequently, the organ becomes stressed with ALT and AST liver enzymes rising. However, anavar is one of the few exceptions to this rule, with it posing considerably less liver toxicity (compared to other orals). It is not entirely known why this is the case, however the kidneys playing more of a role in processing oxandrolone, compared to other compounds, may be a reasonable explanation. Thus, decreasing the liver’s work load. Cholesterol levels will shift in a negative way, thought to be notably less than other steroids; albeit greater than testosterone. For an oral steroid, anavar is certainly not the worst compound for the heart; however its effects are notable. Research has shown that men taking 20mg/day of anavar for 12 weeks, experienced a 30% decrease in HDL cholesterol (8). A 40mg/day dose of anavar only reduced HDL levels by a further 3% ( 33% in total). When taking 80mg/day the reduction was severe, dropping by 50%. LDL levels also increased in each of the groups, at a similar rate to the drop in HDL. The typical bodybuilding dose for men is 20mg of anavar per day. Also is not commonly taken for long periods of time (such as 12 weeks), but more often 6-8 weeks. Thus, a common anavar cycle will likely yield less than a 30% decrease in HDL cholesterol; likely being closer to 20-25%. This is not an alarming drop, however certainly something to monitor and take precautions against. Taking 4g/day of fish oil can help prevent such rises in BP, offering some level of cardiovascular protection on-cycle. Although anavar is viewed as a ‘female friendly’ steroid, virilization (or masculinization) can still occur in women taking high doses of it. Doses over 10mg/day will increase the likelihood of undesirable effects, plus a cycle lasting beyond 6 weeks. Anavar doesn’t convert to estrogen which is a positive in regards to body composition, as there will be no water retention. Consequently, this creates dry and full muscle bellies. Also there is no risk of gynecomastia on anavar, due to a lack of aromatization activity. However, low estrogen is one reason why cholesterol levels are worse on anavar, compared to testosterone. Significant decreases in natural testosterone production is a certainty when taking any steroid. However, anavar will not completely shut down users; but instead cause moderate suppression, steroid shop bulgaria. One study reported a 45% reduction in testosterone, when male subjects took 20mg and 40mg for 12 weeks (9).
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